Protective Effect of Panduratin A on Cisplatin-Induced Apoptosis of Human Renal Proximal Tubular Cells and Acute Kidney Injury in Mice

Background: Cisplatin is an effective chemotherapy but its main side effect, acute kidney injury, limits use. Panduratin A, a bioactive compound extracted from Boesenbergia rotunda, shows several biological activities such as anti-oxidative effects. The present study investigated the nephroprotective effect of panduratin A on cisplatin-induced renal injury. Methods: We toxicity cisplatin in both mice and human cell cultures using RPTEC/TERT1 cells. Results: results demonstrated that ameliorates cells by reducing apoptosis. Mice treated with single intraperitoneal (i.p.) injection (20 mg/kg body weight (BW)) exhibited tubule injury impaired function shown histological examination increased serum creatinine. Co-administration (50 BW) orally improved ameliorated inhibiting activation extracellular signal-regulated kinase (ERK)1/2 caspase 3. In proximal tubular cells, induced apoptosis activating pro-apoptotic proteins (ERK1/2 3), anti-apoptotic protein (Bcl-2). These effects were significantly co-treatment A. Interestingly, did not alter intracellular accumulation cisplatin. It anti-cancer efficacy either colon or non-small lung cancer lines. Conclusions: highlights has potential protective cisplatin’s nephrotoxicity.